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The author of this 1755 work is unknown - John Smith may not even have been his real name - but internal evidence from the book suggests that he may have spent some time in northern Germany, and he also shows familiarity with aspects of French printing. Smith describes the typesetting of books but not the actual printing, so it is possible that he may have been a compositor or a printer's reader. The work is a comprehensive survey of all aspects of typecasting and composition, dealing with the formation of type, regular- and irregular-bodied letters, accents, kerning, upper and lower case, spacing, rules, braces and fleurons, and non-Roman fonts including Greek, Hebrew, black-letter, Old English, and Chinese, as well as mathematical and astronomical symbols and music. There are also sections on casting off copy, composing, imposing and correcting, giving a fascinating account of the eighteenth-century compositor's craft.

Printing

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Langues indo-europeennes --- Nom (grammaire) --- Nom --- Langues indo-européennes --- Noms

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As knowledge of biological systems and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. Smith and Williams' Introduction to the Principles of Drug Design and Action, Fourth Edition provides an introduction to the principles of rational drug design, including both novel and established approaches. This new edition adopts a 'from-bench-to-marketplace' approach, using real examples where possible. In addition to a comprehensive update of the previous edition, new advances in molecular techniques, biotechnological applications and computer-aided design have been added.

Pharmacosynthesis. Pharmacochemistry --- Drugs --- Drug Design. --- Pharmacologic Actions. --- Design. --- Structure-activity relationships. --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena and Processes --- Drug Therapy --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Drug Design --- Pharmacologic Actions --- Pharmacological and Toxicological Phenomena --- Structure-activity relationship (Pharmacology) --- Pharmaceutical chemistry --- Pharmacology --- Structure-activity relationships (Biochemistry) --- Drug design --- Pharmaceutical design --- Drug development --- Design --- Structure-activity relationships --- Computer-Aided Drug Design --- Computerized Drug Design --- Pharmaceutical Design --- Computer Aided Drug Design --- Computer-Aided Drug Designs --- Computerized Drug Designs --- Design, Computer-Aided Drug --- Design, Computerized Drug --- Design, Pharmaceutical --- Designs, Computer-Aided Drug --- Designs, Computerized Drug --- Designs, Pharmaceutical --- Drug Design, Computer-Aided --- Drug Design, Computerized --- Drug Designs, Computer-Aided --- Drug Designs, Computerized --- Pharmaceutical Designs